PEX Genes in Fungal Genomes: Common, Rare or Redundant

Predicting essential genes in fungal genomes.

Essential genes are required for an organism's viability, and the ability to identify these genes in pathogens is crucial to directed drug development. Predicting essential genes through computational methods is appealing because it circumvents expensive and difficult experimental screens. Most such prediction is based on homology mapping to experimentally verified essential genes in model orga...

redundant publication' or 'duplicate publication' in the biomedical literature

Generalised and conditional inactivation of Pex genes in mice.

During the past 10 years, several Pex genes have been knocked out in the mouse with the purpose to generate models to study the pathogenesis of peroxisome biogenesis disorders and/or to investigate the physiological importance of the Pex proteins. More recently, mice with selective inactivation of a Pex gene in particular cell types were created. The metabolic abnormalities in peroxisome defici...

Common Disease: Are Causative Alleles Common or Rare?

It has been said that a week is a long time in politics. But in human disease gene mapping, 10 years can seem a very short time indeed. It once seemed so simple: find a family with a number of affected individuals and narrow down regions of the genome shared by affected individuals but not their unaffected siblings. This process (family linkage analysis) was lengthy but had notable success with...

Aggregating common, rare, and private variants in Alzheimer's disease genes

Chapter 1: Introduction Chapter 2: Background Chapter 3: Materials and Methods Chapter 4: Results Chapter 5: Conclusions References Appendix